Description

This peptide is the fragment of Histone H3 (21-44) with deimination at Arg26, converting it to Cit (citrulline). It is biotinylated through a C-terminal GGK linker. Deimination by peptidyl arginine deiminase 4 (PADI4) blocks methylation by the CARM1 methyltransferase and inhibits transcriptional activation.

SEQUENCE: H-Ala-Thr-Lys-Ala-Ala-Cit-Lys-Ser-Ala-Pro-Ala-Thr-Gly-Gly-Val-Lys-Lys-Pro-His-Arg-Tyr-Arg-Pro-Gly-Gly-Gly-Lys(Biotin)-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: ATKAA-Cit-KSAPATGGVKKPHRYRPGGG-K(Biotin)

MOLECULAR FORMULA:

MOLECULAR WEIGHT: 2975.5

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Miscellaneous

REFERENCES:
Cuthbert, G. et al. Cell 118, 545 (2004)

SKU(s): HIST-057A, HIST-057B

KEYWORDS: