Description

This peptide derived from the V3 loop of HIV IIIB gp120 completely blocks the fusion inhibition activity of antisera to recombinant human HIV proteins. NNTRKSIRIQRGPGRAFVTIGKIG also inhibits the infection of primary human T cells by HIV-1 IIIB, as well as syncytium formation.

SEQUENCE: H-Asn-Asn-Thr-Arg-Lys-Ser-Ile-Arg-Ile-Gln-Arg-Gly-Pro-Gly-Arg-Ala-Phe-Val-Thr-Ile-Gly-Lys-Ile-Gly-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: NNTRKSIRIQRGPGRAFVTIGKIG

MOLECULAR FORMULA: C₁₁₄H₁₉₉N₄₁O₃₁

MOLECULAR WEIGHT: 2640.06

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [115416-08-5]

SYNONYMS: gp120 Fragment 308-331, HIV (gp120) Fragment (308-331);

RESEARCH AREA: Antimicrobial

REFERENCES:
L.Ratner et al., Nature, 313, 277 (1985)
J.R.Rusche et al., Proc. Natl. Acad. Sci. USA, 85, 3198 (1988)
P.N.Nehete et al., J. Virol., 67, 6841 (1993)

SKU(s): HIV-007A, HIV-007B

KEYWORDS: