Description

This IGF-I peptide analog was able to inhibit the autophosphorylation of the IGF-I receptor by IGF-I as well as the growth of several different cell types, including prostate carcinoma cells and SV40-transformed cells. Such analogs might be useful in treating abnormal cell growth.

SEQUENCE: H-Cys-Tyr-Ala-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Cys-OH (trifluoroacetate salt)
(Disulfide bond)

ONE-LETTER SEQUENCE: CYAAPLKPAKSC

MOLECULAR FORMULA: C₅₅H₈₈N₁₄O₁₅S₂

MOLECULAR WEIGHT: 1249.52

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [147819-32-7]

SYNONYMS:

RESEARCH AREA: Diabetes

REFERENCES:
Z.Pietrzkowski et al., Cancer Res., 52, 6447 (1992)
Z.Pietrzkowski et al., Cancer Res., 53, 1102 (1993)
G.Camarero et al., Dev. Biol., 262, 242 (2003)
L.Croci et al., Cell Death Differ., 18, 48 (2011)

SKU(s): ILGF-002A, ILGF-002B

KEYWORDS: