Description

Antileukinate, Ac-RRWWCR-amide, inhibits the specific binding of 125I-labeled IL-8 to neutrophils with an apparent Ki = 10 ?M. The hexapeptide also significantly suppresses neutrophil chemotaxis induced by 10 nM IL-8 at a concentration of 50 ?M. The inhibition is specific for IL-8.

SEQUENCE: Ac-Arg-Arg-Trp-Trp-Cys-Arg-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: Ac-RRWWCR-NH2

MOLECULAR FORMULA: C₄₅H₆₆N₁₈O₇S₁

MOLECULAR WEIGHT: 1003.2

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [138559-60-1]

SYNONYMS:

RESEARCH AREA: Immunomodulation

REFERENCES:
S.Hayashi et al., J. Immunol., 154, 814 (1995)
Y.Fukuno et al., Cytokine, 22, 116 (2003)
X.Lin et al., Am. J. Physiol. Lung Cell. Mol. Physiol., 289, L583 (2005)

SKU(s): ITLK-002A, ITLK-002B

KEYWORDS: