Description

Useful FRET substrate for a continuous fluorescence-based assay of the malaria aspartyl protease (plasmepsin). The peptide sequence ERNleFLSFP is derived from the cleavage site present in hemoglobin, with Nle as a substitution for Met to avoid potential oxidation related problems.

SEQUENCE: DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS (trifluoroacetate salt)

ONE-LETTER SEQUENCE: ERNleFLSFP

MOLECULAR FORMULA: C₇₆H₉₈N₁₆O₁₅S₁

MOLECULAR WEIGHT: 1507.78

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [263718-22-5]

SYNONYMS:

RESEARCH AREA: Antimicrobial

REFERENCES:
M.Pennington et al., Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries, 5th International Symposium, London, p. 367, R.Epton, ed., Mayflower Scientific, (1998)
S.Jiang et al., Antimicrob. Agents Chemother., 45, 2577 (2001)
M.Stadler et al., J. Antibiot., 58, 775 (2005)

SKU(s): MALA-001A, MALA-001B

KEYWORDS: dye-labeled