Description

Highly basic MCD peptide is isolated from the venom of European honeybee, Apis Mellifera. At low doses, it leads to mast cell degranulation and subsequence histamine release. At higher doses, it causes an anti-inflammatory effect, beneficial in rheumatic and allergic diseases.

SEQUENCE: H-Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2 (trifluoroacetate salt)
(Cys3 and 15 bridge, Cys5 and 19 bridge)

ONE-LETTER SEQUENCE: IKCNCKRHVIKPHICRKICGKN-NH2 (C3&C15 bridge, C5&C19 bridge)

MOLECULAR FORMULA: C₁₁₀H₁₉₂N₄₀O₂₄S₄

MOLECULAR WEIGHT: 2587.25

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [32908-73-9]

SYNONYMS: Mast Cell Degranulating (MCD) Peptide, Peptide 401

RESEARCH AREA: Inflammation

REFERENCES:
M.E.J. Billingham et al., Nature, 245, 163 (1973)

SKU(s): MCDP-003A, MCDP-003B

KEYWORDS: