Description

Transdermal Peptide TD-1 Amide is novel peptide designed to enhance transdermal drug delivery. Mechanistic studies suggest that the peptide creates transient opening in the skin barrier, which enables protein-sized molecules to pass through the skin and reach systemic circulation. When TD-1 is co-administrated with insulin on rat skin, systemic levels of insulin and human growth hormone are increased significantly.

SEQUENCE: H-Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly-NH2 (disulfide bridge)

ONE-LETTER SEQUENCE: ACSSSPSKHCG-NH2 (disulfide bridge)

MOLECULAR FORMULA: C₄₀H₆₇N₁₅O₁₅S₂

MOLECULAR WEIGHT: 1060.17

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS: TD-1

RESEARCH AREA: Miscellaneous

REFERENCES:
Chen, Y. et al. Nat. Biotechnol. 24, 455 (2006)

SKU(s): MISC-016A, MISC-016B, MISC-016C

KEYWORDS: peptide macrocycle