Description

First synthetic substrate identified for cleavage by ST3. This fluorogenic peptide provides a simple test for routine assay of ST3 and is useful for ST3 inhibitor screens.

SEQUENCE: MCA-Pro-Leu-Ala-Cys(p-OMeBz)-Trp-Ala-Arg(Dpa)-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2

MOLECULAR FORMULA: C₆₆H₈₂N₁₆O₁₇S₁

MOLECULAR WEIGHT: 1403.5

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [1926163-82-7]

SYNONYMS: MT1-MMP Substrate I, Fluorogenic, Matrix Metalloproteinase-14 Fluorogenic Substrate I, Mca-Pro-Leu-Ala-Cys(p-OMeBz)-Trp-Ala-Arg(Dpa)-NH2, Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2, Mca-Pro-Leu-Ala-Cys(p-OMeBz)-Trp-Ala-Arg-Dap(Dnp)-NH2, Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2

RESEARCH AREA: Cancer

REFERENCES:
A. Mucha, et al., J. Biol. Chem. 273, 2763 (1998)

SKU(s): MMPS-017A, MMPS-017B

KEYWORDS: dye-labeled