Description

A stromelysin-1 substrate, which is also hydrolyzed by two other matrix metalloproteinases, collagenase and gelatinase, and by the bacterial metalloproteinase thermolysin. The thiopeptolide Ac-PLA-psi[COS]Nva-W-amide mimics the MMP-3 cleavage site Leu-Ala-Nva-Trp

SEQUENCE: Ac-Pro-Leu-Ala-[(S)-2-mercapto-pentanoyl]-Trp-NH2

ONE-LETTER SEQUENCE: Ac-PLA-[(S)-2-mercapto-pentanoyl]-W-NH2

MOLECULAR FORMULA: C₃₂H₄₆N₆O₆S₁

MOLECULAR WEIGHT: 642.82

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Cancer

REFERENCES:
R.L.Stein and M.Izquierdo-Martin, Arch. Biochem. Biophys., 308, 274 (1994)
W.Pan et al., J. Biol. Chem., 278, 27820 (2003)

SKU(s): MMPS-028A, MMPS-028B

KEYWORDS: