Description

In contrast to the encephalitogenic rat homolog, this peptide is not a major T-cell epitope in multiple sclerosis propably due to its lower amount of helical structure formed when dissolved in micellar sodium dodecyl sulfate. This peptide induced anti-MOG(35-55) autoantibody production in C57BL/6 mice.

SEQUENCE: H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Pro-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: MEVGWYRPPFSRVVHLYRNGK

MOLECULAR FORMULA: C₁₂₀H₁₇₉N₃₅O₂₈S₁

MOLECULAR WEIGHT: 2592.03

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [163158-19-8]

SYNONYMS:

RESEARCH AREA: Multiple Sclerosis

REFERENCES:
N.Kerlero de Rosbo et al., Eur. J. Immunol., 27, 3059 (1997)
S.Albouz-Abo et al., Eur. J. Biochem., 246, 59 (1997)
M.F.Mesleh et al., Neurobiol. Dis., 9, 160 (2002)
Oliver, A. J. Immunology 171, 462 (2003)
Stromnes, I. et al. Nature protocols 1, 1810 (2006)

SKU(s): MOG-002A, MOG-002B

KEYWORDS: