Description

Urodilatin (95-126) originally extracted from human urine that corresponds to the family of natriuretic-vasorelaxant peptides found earlier in heart atria. Infusion of this peptide is found to represent a concept for the treatment of therapy-resistant acute renal failure after liver transplantion. The use of NATR-004 is protected by patents.

SEQUENCE: H-Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (trifluoroacetate salt)
(Cys11 and 27 bridge)

ONE-LETTER SEQUENCE: TAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRY (C11&C27 bridge)

MOLECULAR FORMULA: C₁₄₅H₂₃₄N₅₂O₄₄S₃

MOLECULAR WEIGHT: 3506

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [115966-23-9]

SYNONYMS:

RESEARCH AREA: Cardiovascular

REFERENCES:
P. Schultz-Knappe et al., Klin. Wochenschr., 66, 752 (1988)

SKU(s): NATR-004A, NATR-004B

KEYWORDS: hormone