Description

This peptide is a modulator of arousal and possibly anxiety-related behaviour. It acts by activating its cognate receptor (NPSR) and inducing mobilization of intracellular Ca2+. Central administration of NPS induced wakefulness and reduced slow wave and REM sleep in rats. These peptides represent potential lead compounds for the treatment of sleep and anxiety disorders.

SEQUENCE: H-Ser-Phe-Arg-Asn-Gly-Val-Gly-Ser-Gly-Val-Lys-Lys-Thr-Ser-Phe-Arg-Arg-Ala-Lys-Gln-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: SFRNGVGSGNKKTSFRRAKQ

MOLECULAR FORMULA: C₉₅H₁₆₀N₃₄O₂₇

MOLECULAR WEIGHT: 2210.53

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [412938-75-1]

SYNONYMS:

RESEARCH AREA: Neuropeptides

REFERENCES:
Y.-L.Xu et al., Neuron, 43, 487 (2004)
N.Okamura and N.K.Reinscheid, Stress, 10, 221 (2007)
K.Domschke et al., Mol. Psychiatry, 16, 938 (2011)

SKU(s): NEUP-012A, NEUP-012B

KEYWORDS: