Description

This peptide is an endogenous ligand of the G-protein-coupled receptors GPR7 and GPR8. It dose-dependently inhibited cAMP accumulation induced by forskolin in CHO-GPR7 and CHO-GPR8 cells, with IC50 values of 0.025 and 0.178 nM, respectively. Intracerebroventricular administration of neuropeptide W-23 (human) in rats increased food intake and stimulated prolactin release.

SEQUENCE: H-Trp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ala-Gly-Leu-Leu-Met-Gly-Leu-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: WYKHVASPRYHTVGRAAGLLMGL

MOLECULAR FORMULA: C₁₁₉H₁₈₃N₃₅O₂₈S₁

MOLECULAR WEIGHT: 2584.05

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [383415-79-0]

SYNONYMS:

RESEARCH AREA: Neuropeptides

REFERENCES:
.Shimomura et al., J. Biol. Chem., 277, 35826 (2002)
S.Brezillon et al., J. Biol. Chem., 278, 776 (2003)
H.Tanaka et al., Proc. Natl. Acad. Sci. USA, 100, 6251 (2003)
M.S.Mondal et al., Endocrinology, 144, 4729 (2003)

SKU(s): NEUP-013A, NEUP-013B

KEYWORDS: