Description

This peptide was recently identified as the endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8 which are expressed in the central nervous system. NPW-30 activated and bound to both GPR7 and GPR8 at similar effective doses. Intracerebroventricular administration of NPW in rats resulted in an increased food intake and stimulation of prolactin release indicating that NPW acts as a mediator of the central control of feeding and the neuroendocrine system.

SEQUENCE: H-Trp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ala-Gly-Leu-Leu-Met-Gly-Leu-Arg-Arg-Ser-Pro-Tyr-Leu-Trp-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: WYKHVASPRYHTVGRAAGLLMGLRRSPYLW

MOLECULAR FORMULA: C₁₆₅H₂₄₉N₄₉O₃₇S₁

MOLECULAR WEIGHT: 3543.17

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [383415-80-3]

SYNONYMS:

RESEARCH AREA: Neuropeptides

REFERENCES:
Y.Shimomura et al., J. Biol. Chem., 277, 35826 (2002)
S.Brezillon et al., J. Biol. Chem., 278, 776 (2003)
H.Tanaka et al., Proc. Natl. Acad. Sci. USA, 100, 6251 (2003)

SKU(s): NEUP-014A, NEUP-014B

KEYWORDS: