Description

Hypothalamic neuropeptide that regulates feeding behavior and significantly augments food intake in a dose-dependent manner when a bolus is administered intracerebroventricularly. After a 48-hour fast, hypothalamic prpro-orexin mRNA level is up-regulated 2.4. The discovery of orexins and their receptors may provide a novel molecular basis for understanding the role of the lateral hypothalamic areas in the regulation of energy homeostasis.

SEQUENCE: H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2

MOLECULAR FORMULA: C₁₂₃H₂₁₂N₄₄O₃₅S₁

MOLECULAR WEIGHT: 2898.39

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [205640-91-1]

SYNONYMS: Hypocretin-2 (human)

RESEARCH AREA: Obesity

REFERENCES:
M.W. Schwartz, Nat. Med., 4, 385 (1998)
T. Sakurai et al., Cell, 92, 573 (1998)

SKU(s): OREX-002A, OREX-002B

KEYWORDS: hormone