Description

This peptide was originally isolated from cultured regenerating rat bone marrow, which is identical in sequence to the C-terminus of histone H4. Synthetic OGP stimulates the proliferation and alkaline phosphatase activity of osteoblastic cells in vitro and increases bone mass in rats when injected in vivo. This peptide may therefore represent a new class of molecules involved in the systemic control of osteoblast proliferation and differentiation.

SEQUENCE: H-Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Tyr-Gly-Phe-Gly-Gly-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: ALKRQGRTLYGFGG

MOLECULAR FORMULA: C₆₈H₁₁₀N₂₂O₁₈

MOLECULAR WEIGHT: 1523.76

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [132996-61-3]

SYNONYMS:

RESEARCH AREA: Osteoporosis

REFERENCES:
I.Bab et al., EMBO J., 11, 1867 (1992)
Z.Greenberg et al., Biochim. Biophys. Acta, 1178, 273 (1993)
Z.Greenberg et al., J. Cell. Biochem., 65, 359 (1997)

SKU(s): OSTP-007A, OSTP-007B

KEYWORDS: