Description

Carbocalcitonin, the amino-suberic acid analog of eel calcitonin, has all the biological properties of the corresponding natural calcitonin. The substitution of the disulfide bond of natural calcitonins with an ethylene bridge in the 1-7 N-terminal position gives elcatonin greater stability and excellent tolerability when used in vivo.

SEQUENCE: H-Ser-Asn-Leu-Ser-Thr-Asu-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ala-Gly-Thr-Pro-NH2 (trifluoroacetate salt)
(Peptide bond Ser1 and Asu6 bridge)

ONE-LETTER SEQUENCE: SNLST-Asu-VLGKLSQELHKLQTYPRTDVGAGTP-NH2
(Peptide bond Ser1 and Asu6 bridge)

MOLECULAR FORMULA: C₁₄₇H₂₄₂N₄₂O₄₇

MOLECULAR WEIGHT: 3363.82

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [60731-46-6]

SYNONYMS: Elcatonin, (Asu¹·⁷)-Calcitonin (eel), (Des-Cys¹,cyclo(Ser²-Asu⁷))-Calcitonin (eel)

RESEARCH AREA: Osteoporosis

REFERENCES:
A. Caniggia et al., Minerva Medica , 74, 993 (1983)
Italian Osteoporosis Network, Current Therapeutic Res., 45, 502 (1989)

SKU(s): OSTP-013A, OSTP-013B

KEYWORDS: hormone, lactam, peptide macrocycle