Description

Atosiban is a nonapeptide, desamino-oxytocin analogue, and a competitive vasopressin/oxytocin receptor antagonist (VOTra). Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a consequence, reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells and reduced influx of Ca2+ from the extracellular space through voltage-gated channels occur. Atosiban also suppresses oxytocin-mediated release of PGE and PGF from the decidua.

SEQUENCE: 3-Mercaptopropionyl-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-NH2 (acetate salt)
(Disulfide bond)

ONE-LETTER SEQUENCE: 3-Mercaptopropionyl-y(Et)-ITNCP-Orn-G-NH2

MOLECULAR FORMULA: C₄₃H₆₇N₁₁O₁₂S₂

MOLECULAR WEIGHT: 994.19

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [90779-69-4]

SYNONYMS:
(Mpa(1),D-Tyr(Et)2,Thr(4),Orn(8))oxytocin, (Mpa(1)-D-Tyr(Et)(2)-Thr(4)-Orn(8))-oxytocin, 1-deamino-2-Tyr(OEt)-4-Thr-8-Orn-oxytocin

RESEARCH AREA: Hormonal

REFERENCES:
M.Akerlund, Prog. Brain Res., 139, 359 (2002)
H.H.Zingg and S.A.Laporte, Trends Endocrinol. Metab., 14, 222 (2003)
M.Manning et al., Prog. Brain Res., 170, 473 (2008)

SKU(s): OXYT-003A, OXYT-003B

KEYWORDS: