Description

The peptide T1 is the thrombin receptor domain, which functions as a tethered ligand for the receptor itself. T1 is an inhibitor of thrombin triggered platelet aggregation, serotonin release and tyrosine phosphorylation. Its anti-aggregatory activity was about ten-fold higher than that of the previously reported peptide antagonists of the thrombin receptor. This peptide has served as model peptide in protein modification and MS studies.

SEQUENCE: H-Met-Ser-Arg-Pro-Ala-Cys-Pro-Asn-Asp-Lys-Tyr-Glu-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: MSRPACPNDKYE

MOLECULAR FORMULA: C₅₈H₉₁N₁₇O₂₀S₂

MOLECULAR WEIGHT: 1410.6

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [207553-92-2]

SYNONYMS:

RESEARCH AREA: Hematology

REFERENCES:
J.Doorbar and G.Winter, J. Mol. Biol., 244, 361 (1994)
H.Schafberg et al., Br. J. Cancer, 76, 1592 (1997)
R.Kaufmann et al., NeuroReport, 9, 709 (1998)
H.Y.Tang and D.W.Speicher, Anal. Biochem., 334, 48 (2004)
M.C.Sun et al., J. Sep. Sci., 31, 538 (2008)

SKU(s): PARP-002A, PARP-002B

KEYWORDS: