Description

This peptide inhibited activation of PAR-2 by trypsin in PAR-2 receptor expressing KNRK cells. Half-maximal inhibition of calcium signaling was observed at about 50 ?M. In contrast, the activation of PAR-2 by SLIGRL-NH2 (PAR-2 (1-6) amide (mouse, rat)) was not inhibited by this peptide. Selective Antagonist for PAR2 Agonist. This peptide blocks trypsin but not SLIGRL-NH2 activation of PAR2 in receptor-expressing KNRK cells.

SEQUENCE: H-Phe-Ser-Leu-Leu-Arg-Tyr-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: FSLLRY-NH2

MOLECULAR FORMULA: C₃₉H₆₀N₁₀O₈

MOLECULAR WEIGHT: 796.97

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [245329-02-6]

SYNONYMS:

RESEARCH AREA: Hematology

REFERENCES:
B.Al-Ani et al., J. Pharmacol. Exp. Ther., 300, 702 (2002)
S.Wilson et al., Biochem. J., 388, 967 (2005)

SKU(s): PARP-004A, PARP-004B

KEYWORDS: