Description

This peptide is the amino terminus of the fourth protease-activated receptor (PAR4) after the cleavage at Arg47/Gly48 was tested for its ability to stimulate COS cells expressing PAR4. The peptide readily activated both wild-type and mutant PAR4 (R47A) at 500 µM, whereas thrombin and trypsin only activate the wild-type PAR4.

SEQUENCE: H-Gly-Tyr-Pro-Gly-Gln-Val-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: GYPGQV

MOLECULAR FORMULA: C₂₈H₄₁N₇O₉

MOLECULAR WEIGHT: 619.68

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [225779-44-2]

SYNONYMS: Proteinase Activated Receptor 4 (1-6) (human), GYPGQV, Thrombin Receptor-Like 3 (1-6) (human), Coagulation Factor II Receptor-Like 3 (1-6) (human)

RESEARCH AREA: Hematology

REFERENCES:
W.-F.Xu et al., Proc. Natl. Acad. Sci. USA, 95, 6642 (1998)
H.Andersen et al., Proc. Natl. Acad. Sci. USA, 96, 11189 (1999)
R.Kaufmann et al., J. Cancer Res. Clin. Oncol., 126, 91 (2000)

SKU(s): PARP-010A, PARP-010B

KEYWORDS: