Description

Protease-activated receptor-4 activating peptide derived from murine PAR-4. This peptide was able to cause rat platelet aggregation with an EC50 value of 40 ?M. Its effect on leucocyte rolling and adherence points at a role of PAR-4 in mediating proinflammatory processes. The family of at least seven transmembrane G protein coupled receptors includes at least four receptor subtypes (PAR1, PAR2, PAR3, PAR4). PAR4 activating peptides, GYPGKF-NH2 and AYPGKG-NH2, produce concentration dependent contractile effects on the muscle.

SEQUENCE: H-Gly-Tyr-Pro-Gly-Lys-Phe-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: GYPGKF-NH2

MOLECULAR FORMULA: C₃₃H₄₆N₈O₇

MOLECULAR WEIGHT: 666.78

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [245443-52-1]

SYNONYMS:

RESEARCH AREA: Hematology

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SKU(s): PARP-014A, PARP-014B

KEYWORDS: