Description

This peptide is a 14-amino acid peptide mimicking the potent thrombin receptor activator as well as an effective agonist for platelet activation. This peptide is the fragment 42-55 of the human thrombin receptor and fully reproduces the action of thrombin on MMPs in vascular endothelial cells. This peptide (TRP-14) may signal a variety of thrombin?s responses and has been shown to cause platelet aggregation that can evoke a wide range of G-protein dependent responses.

SEQUENCE: H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: SFLLRNPNDKYEPF

MOLECULAR FORMULA: C₈₁H₁₁₈N₂₀O₂₃

MOLECULAR WEIGHT: 1739.95

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [137339-65-2]

SYNONYMS:

RESEARCH AREA: Hematology

REFERENCES:
T.-K.H.Vu et al., Cell, 64, 1057 (1991)
Y.Maruyama et al., Biochem. Biophys. Res. Commun., 199, 1262 (1994)
Duhamel-Clérin, E. et al. Arterioscler. Thromb. Vasc. Biol. 17, 1931 (1997)
Vassallo, R. et al. J. Biol. Chem. 267, 6081 (1992)
Y. Sugama and AB. Malik. Circ. Res. 71, 1015 (1992)

SKU(s): PARP-022A, PARP-022B

KEYWORDS: