Description

This peptide can inhibit monocyte spreading on fibronectin-coated slides. The rapidly induced withdrawal of pseudopodial processes and rounding of the cells is accompanied by nitric oxide and endothelin-1 release. Spreading might be inhibited by autocrine endothelin-1 release and subsequent endothelin B receptor-dependent nitric oxide production

SEQUENCE: H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: SFLLRNPNDKYEPF-NH2

MOLECULAR FORMULA: C₈₁H₁₁₉N₂₁O₂₂

MOLECULAR WEIGHT: 1738.96

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [141923-36-6]

SYNONYMS:

RESEARCH AREA: Hematology

REFERENCES:
K.D.Srivastava and H.I.Magazine, J. Immunol., 161, 5039 (1998)
J.R. Ngaiza and E.A. Jaffe, Biochem. Biophys. Res. Commun., 179, 1656 (1991)
D.M. Feng, D.F. Veber, T.M. Connolly, C. Condra, M.J. Tang, and R.F. Nutt, J. Med. Chem.,38,4125 (1995)

SKU(s): PARP-023A, PARP-023B

KEYWORDS: