Description

26-residue polypeptide isolated from bee venom that binds calmodulin in a Ca2+ dependent manner, activates phospholipase A2, and inhibits protein kinase C (IC50 = 5-7 m M) by binding to the catalytic domain in a Mg-ATP sensitive manner. IC50 of 1-4 µM.

SEQUENCE: H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: GIGAVLKVLTTGLPALISWIKRKRQQ-NH2

MOLECULAR FORMULA: C₁₃₁H₂₂₉N₃₉O₃₁

MOLECULAR WEIGHT: 2846.46

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [20449-79-0]

SYNONYMS:

RESEARCH AREA: Protein Kinases and Phosphatases

REFERENCES:
Raynor et al., J. Biol. Chem., 266, 2753 (1991)
Schweitz, Toxicon, 22, 308 (1984)

SKU(s): PKCP-018A, PKCP-018B

KEYWORDS: