Description

This 14-mer prosaptide sequence is derived from the active neurotrophic region in the amino-terminal portion of the saposin C domain. Synthetic peptides derived from this region are biologically active and are named ?prosaptides.? Prosaposin and prosaptides are active on a variety of neuronal cells, stimulating sulfatide synthesis and increasing sulfatide concentration in Schwann cells and oligodendrocytes. This indicates that prosaposin and prosaptides are trophic factors for myelin formation.

SEQUENCE: H-Thr-D-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: TaLIDNNATEEILY

MOLECULAR FORMULA: C₆₉H₁₁₀N₁₆O₂₆

MOLECULAR WEIGHT: 1579.70

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [196391-82-9]

SYNONYMS:

RESEARCH AREA: Neuropeptides

REFERENCES:
Campana, M. et al. FASEB J. 12, 307 (1998)
Hiraiwa, M. et al. Proc. Natl. Acad. Sci. USA 94, 4778 (1997)
Taylor, E. et al. Pharmacol. 295, 190 (2000)
Calcutt, NA. et al. Anesthesiology 93, 1271 (2000).

SKU(s): PROS-001A, PROS-001B

KEYWORDS: