Description

This peptide increases membrane microviscosity, intracellular Ca2+ concentration and cell migration in circulating leucocytes, and oxygen production in monocytes and neutrophils. It also induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell lines. PrP (106?126) stimulates leucocyte migration in a dose-dependent manner.

SEQUENCE: H-Lys-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Ala-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: KTNMKHMAGAAAAGAVVGGLG

MOLECULAR FORMULA: C₈₀H₁₃₈N₂₆O₂₄S₂

MOLECULAR WEIGHT: 1912.3

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [148439-49-0]

SYNONYMS:

RESEARCH AREA: Antimicrobial

REFERENCES:
Diomede, L. et al. Biochem. J. 320, 563 (1996) Florio, T. et al. J. Neurosci. Res. 54, 341 (1998).

SKU(s): PRPR-001A

KEYWORDS: