Description

This peptide is a renin substrate (angiotensinogen) labeled with EDANS/ DABCYL FRET pair for renin activity studies. The renin-angiotensin system (RAS), acting through type 1 angiotensin (AT1) receptors, is a master regulator of fluid homeostasis.

SEQUENCE: H-Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: R-E(EDANS)-IHPFHLVIHT-K(DABCYL)-R

MOLECULAR FORMULA: C₁₀₉H₁₅₆N₃₂O₂₁S

MOLECULAR WEIGHT: 2282.71

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS: Renin 390 FRET Substrate

RESEARCH AREA: Cardiovascular

REFERENCES:
Crowley, S. et al. J. Clin. Invest. 115, 1092 (2005)
Holzman, T. et al. J. Protein Chem. 9, 663 (1990).

SKU(s): RENI-012A

KEYWORDS: dye-labeled