Description

This fluorogenic peptide substrate was developed to continuously measure proteolytic activity of human renin (Km = 1.5 mM)). Cleavage of the substrate occurs selectively at the Leu-Val bond and corresponds to the renin cleavage site of angiotensinogen.

SEQUENCE: DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS (trifluoroacetate salt)

ONE-LETTER SEQUENCE: DABCYL-gamma-Abu-IHPFHLVIHT-EDANS

MOLECULAR FORMULA: C₉₀H₁₂₀N₂₂O₁₆S

MOLECULAR WEIGHT: 1798.15

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [142988-22-5]

SYNONYMS:

RESEARCH AREA: Cardiovascular

REFERENCES:
Wang GT, et al. Anal Biochem (1993) 210, 351-9.
Nakamura N, et al. J Biochem (Tokyo) (1991) 109, 741-5.
Murakami K, et al. Anal Biochem (1981) 110, 232-9.

SKU(s): RENI-013A

KEYWORDS: dye-labeled