Description

This is a Pannexin-1 (Panx1) mimetic blocking peptide. Pannexin-1 is a recently identified membrane protein that can form gap junction-like connections allowing intercellular passage of dyes when overexpressed in two adjacent oocytes or mammalian epithelial cell lines. Blockade of pannexin-1 in macrophage endogenously expressing the ATP-gated P2X7 receptor (P2X7R) blocks the initial dye uptake, but not the ionic current, and also blocks processing and release of interleukin-1α (IL-1α) in response to P2X7R activation.

SEQUENCE: H-Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: WRQAAFVDSY

MOLECULAR FORMULA: C₅₈H₇₉N₁₅O₁₆

MOLECULAR WEIGHT: 1242.4

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Protein Kinases and Phosphatases

REFERENCES:
Pelegrin, P. et al. EMBO. J. 25, 5071 (2006)
Pelegrin, P. et al.t J. Biol. Chem. 282, 2386 (2007).

SKU(s): SIGN-011A

KEYWORDS: