Description

Two monoclonal antibodies (MAbs), reactive with the external envelope glycoprotein of the simian immunodeficiency virus of macaque monkey and displaying a cellfree virus-neutralizing activity, were generated. Epitope mapping of these MAbs permitted to delineate a neutralizing domain localized in the second variable region of the SIVmac251 gp105, between amino acids 171 and 188. This domain is enclosed in the above sequence. In addition, this neutralizing domain usually induces a specific humoral response in experimentally SIVmac-infected macaques.

SEQUENCE: H-Lys-Phe-Thr-Met-Thr-Gly-Leu-Lys-Arg-Asp-Lys-Thr-Lys-Glu-Tyr-Asn-Glu-Thr-Trp-Tyr-Cys-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: LFTMTGLKRDKTKEYNETWYC

MOLECULAR FORMULA: C₁₁₈H₁₈₀N₃₀O₃₅S₂

MOLECULAR WEIGHT: 2643.04

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS: gp160e fragments, Simian immunodeficiency virus (SIV) gp140 fragments

RESEARCH AREA: Antimicrobial

REFERENCES:
K.A.Kent et al., AIDS, 5, 829 (1991)

SKU(s): SIVM-001A, SIVM-001B

KEYWORDS: