Description

This NYAD-2 peptide is NYAD-1 labeled with FITC (Ex/Em=493/517 nm). NYAD-1 is a cell-penetrating alpha-helical peptide used as a potential HIV-1 inhibitor. The hydrocarbon-stapled structure enhances alpha helicity.

SEQUENCE: FITC-(beta-Ala)-Ile-Thr-Phe-X-Asp-Leu-Leu-X-Tyr-Tyr-Gly-Pro-NH2 (olefin metathesis to incorporate double bond, X= (S)-alpha-(2′-pentenyl)alanine)

ONE-LETTER SEQUENCE: FITC-(beta-A)-ITFXDLLXYYGP-NH2 (olefin metathesis to incorporate double bond, X= (S)-alpha-(2′-pentenyl)alanine)

MOLECULAR FORMULA: C₉₈H₁₂₃N₁₅O₂₃S

MOLECULAR WEIGHT: 1911.3

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Antimicrobial

REFERENCES:
Zhang, H. et al. J. Mol. Biol. 378, 565 (2008)

SKU(s): STAP-001A, STAP-002B

KEYWORDS: dye-labeled, macrocycle, stapled