Description

This is the most characterized fragment of the HIV transactivator protein (TAT). This arginine-rich TAT peptide penetrates plasma membrane directly, but not through endocytosis, and has been proven to promote the entry of nucleic acids into several cell types.

SEQUENCE: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: YGRKKRRQRRR

MOLECULAR FORMULA: C₆₄H₁₁₈N₃₂O₁₄

MOLECULAR WEIGHT: 1559.85

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [191936-91-1]

SYNONYMS: HIV-1 tat Protein (47-57)

RESEARCH AREA: Antimicrobial

REFERENCES:
C. Rudolph, et al.,JBC Papers in Press, M211891200, (2003)
V.P. Torchilin, et al., PNAS, 100, 1972-1977, (2003)
Wang, H. et al. J. Clin. Invest. 109, 1463 (2002)
Ziegler et al. Biochem. 44, 138 (2005)
Wender, PA. et al. Proc. Natl. Acad. Sci. USA 97, 13003 (2000)

SKU(s): TAT-002A, TAT-002B

KEYWORDS: