Description

TAU proteins belong to the microtubule-associated protein (MAP) family and are involved in the pathogenesis of Alzheimer?s disease. In the human brain, there are six TAU isoforms ranging from 352 to 441 amino acids in length. These isoforms vary at the carboxyl terminal according to the presence of either three repeat or four repeat domains (R1-R4), in addition to the presence or absence of one or two insert domains at the amino-terminus (see figure below). Tau Peptide (306-336) is a 31-amino acid long peptide derived from the Repeat 3 domain.

SEQUENCE: H-Val-Gln-Ile-Val-Tyr-Lys-Pro-Val-Asp-Leu-Ser-Lys-Val-Thr-Ser-Lys-Cys-Gly-Ser-Leu-Gly-Asn-Ile-His-His-Lys-Pro-Gly-Gly-Gly-Gln-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQ

MOLECULAR FORMULA: C₁₄₃H₂₃₆N₄₂O₄₂S₁

MOLECULAR WEIGHT: 3247.77

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [330456-26-3]

SYNONYMS:

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:
Buee, L. et al. Brain Res Rev 33 95 (2000). Trinczek, B. et al. Mol Biol Cell 6, 1887 (1995).

SKU(s): TAUP-005A, TAUP-005B

KEYWORDS: