This peptide, a double cyclic peptide, binds preferentially to integrins at sites of tumor angiogenesis and inflammed synovium in-vivo, and can be internalized into targeted cells

SEQUENCE: H-Ala-Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys-Gly-OH (trifluoroacetate salt)
(Disulfide bridge: 2-10 and 4-8)

ONE-LETTER SEQUENCE: ACDCRGDCFCG (Disulfide bridge: 2-10 and 4-8)

MOLECULAR FORMULA: C₄₂H₆₀N₁₄O₁₆S₄

MOLECULAR WEIGHT: 1145.29

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [332179-76-7]

SYNONYMS:

RESEARCH AREA: Cancer

REFERENCES:
Curnis, F. et al. Cancer Res. 64, 565 (2004)
Su, Z. et al. Bioconjug. Chem. 13, 561 (2002)
Gerlag, M. et al. Arthritis Res. 3, 357 (2001)
Ellerby, H. et al. Nature Med. 5, 1032 (1999)

SKU(s): THRO-005A, THRO-005B

KEYWORDS: peptide macrocycle