Description

This is a negative control peptide containing the reversed sequence of the first two amino acids of the receptor-activating (tethered ligand) peptide SFLLRN-NH2. It shows no detectable affinity for the binding sites. Whereas SFLLRN-NH2 effectively displaces [3H]haTRAP, thrombin receptor-activating peptide, the same peptide with serine and phenylalanine reversed, FSLLRN-NH2, does not.

SEQUENCE: H-Phe-Ser-Leu-Leu-Arg-Asn-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: FSLLRN-NH2

MOLECULAR FORMULA: C₃₄H₅₇N₁₁O₈

MOLECULAR WEIGHT: 747.89

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [374898-11-0]

SYNONYMS: (Phe¹,Ser²)-Thrombin Receptor Activator Peptide 6, (Phe¹,Ser²)-Thrombin Receptor 1 (1-6) (human), (Phe¹,Ser²)-PAR-1 (1-6) (human), (Phe¹,Ser²)-Proteinase Activated Receptor 1 (1-6) (human), FSLLRN, (Phe¹,Ser²)-Coagulation Factor II Receptor (1-6) (human)

RESEARCH AREA: Hematology, Cardiovascular

REFERENCES:
Ahn, HS. et al. Mol. Pharmacol. 51, 350 (1997)

SKU(s): THRO-006A, THRO-006B

KEYWORDS: