Description

Peptide that is more potent than CRF at binding and activating type-2 CRF receptors and shares ~95% sequence with human version. As a mammalian neuropeptide related to fish urotensin and corticotropin-releasing factor, it also serves as an inducer of c-Fos in regions enriched in type-2 CRF receptors.

SEQUENCE: H-Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2

MOLECULAR FORMULA: C₂₀₆H₃₃₈N₆₂O₆₄

MOLECULAR WEIGHT: 4707.33

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [171543-83-2]

SYNONYMS:

RESEARCH AREA: Neuropeptides

REFERENCES:
J. Vaughan et al, Nature, 378, 287(1995)

SKU(s): UROC-002A, UROC-002B

KEYWORDS: