Description

This peptide has exhibited considerably higher affinity for both splice variants of the type 2 CRF receptor (CRF-R2) than for those of CRF-R1. The potencies of Ucn II (mouse) in activating CRF-R2a and CRF-R2b were almost the same to that of urocortin (rat).

SEQUENCE: H-Val-Ile-Leu-Ser-Leu-Asp-Val-Pro-Ile-Gly-Leu-Leu-Arg-Ile-Leu-Leu-Glu-Gln-Ala-Arg-Tyr-Lys-Ala-Ala-Arg-Asn-Gln-Ala-Ala-Thr-Asn-Ala-Gln-Ile-Leu-Ala-His-Val-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: VILSLDVPIGLLRILLEQARYKAARNQAATNAQILAHV-NH2

MOLECULAR FORMULA: C₁₈₇H₃₂₀N₅₆O₅₀

MOLECULAR WEIGHT: 4153

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [330648-32-3]

SYNONYMS:

RESEARCH AREA: Neuropeptides

REFERENCES:
K.Lewis et al., Proc. Natl. Acad. Sci. USA , 98, 7570 (2001)
S.Y.Hsu et al., Nature Medicine 7, 605 (2001)
T.M.Reyes et al., Proc. Natl. Acad. Sci. USA , 98, 2843 (2001)

SKU(s): UROC-005A, UROC-005B

KEYWORDS: