Description

A vasoactive “somatostatin-like” cyclic peptide originally derived from fish spinal cords that has recently been cloned from man. It was found to be the most potent mammalian vasoconstrictor identified so far and may have additional activities, as urotensin II immunoreactivity was also found within the central nervous system and endocrine tissues.

SEQUENCE: H-Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH (trifluoroacetate salt)
(Cys5 and 10 bridge)

ONE-LETTER SEQUENCE: ETPDCFWKYCV (Cys5 and 10 bridge)

MOLECULAR FORMULA: C₆₄H₈₅N₁₃O₁₈S₂

MOLECULAR WEIGHT: 1388.59

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [251293-28-4]

SYNONYMS: U-II (human), Urotensin II (human), UTS2, UrotensinII(human), Urotensin 2

RESEARCH AREA: Cardiovascular

REFERENCES:
K.L.Ong et al., Cardiovasc. Drugs Ther., 19, 65 (2005)
R.S.Ames et al., Nature, 401, 282 (1999)
Y.Coulouarn et al., Proc. Natl. Acad. Sci. USA, 95, 15803 (1998)

SKU(s): UROT-003A, UROT-003B

KEYWORDS: