Description

A 28 amino acid peptide synthesized in the central nervous system and gastrointestinal tract. It belongs to the secretin glucagon-CRF family and is widely distributed in the central and peripheral nervous systems. In acting as both a neurotransmitter and hormone that has powerful hypotensive and vasodilatory effects, this peptide plays a wide role in a range of biological activities, including vaso- and bronchodilation, smooth muscle relaxation, and stimulation of secretin. When paired with the adrenegic drug phentolamine and injected, this peptide is expected to provide a new and effective solution for patients suffering from erectile dysfunction.

SEQUENCE: H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2

ONE-LETTER SEQUENCE: HSDAVFTDNYTRLRKQMAVKKYLNSILN-NH2

MOLECULAR FORMULA: C₁₄₇H₂₃₈N₄₄O₄₂S₁

MOLECULAR WEIGHT: 3325.80

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [40077-57-4]

SYNONYMS: Aviptadil, VIP (human, mouse, rat)

RESEARCH AREA: Gastrointestinal

REFERENCES:
J.J. Segura et al., Reg. Pep., 37, 145 (1992)

SKU(s): VIP-001A, VIP-001B, VIP-001C

KEYWORDS: hormone