"The tandem peptide library used in this work was synthesized via standard FMOC solid-phase peptide synthesis and purified by high-performance liquid chromatography at the MIT Biopolymers Core, Tufts University Core Facility or CPC Scientific, Inc."
Abstract
Aspects of the invention provide compositions and methods for delivering nucleic acids to target cells.
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Karlsson, Erik A., et al. mBio 7.4 (2016): e01144-16.
"Peptides 20 amino acids in length spanning the HA and NA proteins of the A/Anhui/1/2013 (H7N9) virus were generated with 15-amino-acid overlaps, resulting in the synthesis of 110 HA peptides and 90 NA peptides synthesized at >90% purity (CPC Scientific). A small number of peptides were synthesized at >70% purity, following multiple synthesis and purification attempts. A poly(K) linker was added to each peptide to increase solubility and to improve the binding orientation of peptides to the Hydrogel slides."
August 2nd, 2016Citations, Peptide LibrariesSkerratt, Sarah E., Sian Humphreys, Rita Ferreira, Csilla Jorgensen, Joe Warmus, Lei Zhao, Xiaohe Tong, and Sarah A. Nickolls. MedChemComm 7, no. 8 (2016): 1564-1571.
- Pfizer Neusentis, The Portway Building, Granta Park, Cambridge, UK.
- Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, USA.
- CPC Scientific Inc., 1245 Reamwood Avenue, Sunnyvale, CA 94089, USA.
"antipeptide (EGVYVHPV), angiotensin II, human (DRVYIHPF), and isotopically (13C) labeled heptapeptide (AAAAHAA-NH2 [where “A” indicates a carbon thirteen (13C) "Synthesis was conducted at CPC Scientific Inc. Ac-Asp(OtBu)-Thr(tBu)-His(Trt)-Phe-Pro-Ile-Cys(Trt)-Ile-PhePEG3-Arg(Pbf)-Arg(Pbf)-Lys(Boc)-wang resin (2).. Ac-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-PEG3-Arg-Arg-Lys(BODIPY_TMR_C6)."
August 1st, 2016Citations, coauthored, Metal Chelates, PEGylation, publicationsFumakia, M. MS Thesis, University of Manitoba 2016.
LL37 (host defense peptide) (Table 2) was a purchased from (custom synthesized by CPC Scientific Inc., CA, USA)
July 22nd, 2016Antimicrobial Peptides, Citations, Cosmetic PeptidesKwon, Ester J., Matthew Skalak, Riana Lo Bu, and Sangeeta N. Bhatia. ACS Nano 10, no. 8 (2016): 7926-7933.
"[The peptides] were synthesized by CPC Scientific with N-terminal myristic acid."
July 18th, 2016Citations, LipidationChappell, D.L., Lee, A.Y., Bernstein, H.S., Lassman, M.E. and Laterza, O.F. Bioanalysis 8, no. 22 (2016): 2341-2349.
- Merck & Co., Inc. Rahway, NJ07065, USA
July 15th, 2016CitationsShcherbatko, Anatoly, Andrea Rossi, Davide Foletti, Guoyun Zhu, Oren Bogin, Meritxell Galindo Casas, Mathias Rickert et al. Journal of Biological Chemistry 291, no. 27 (2016): 13974-13986.
- Rinat Laboratories, Pfizer Inc., South San Francisco, California 94080
Large scale preparations were performed based on the described protocol by CPC Scientific.
July 1st, 2016CitationsCox, J.M., Berna, M.J., Jin, Z., Cox, A.L., Sloop, K.W., Gutierrez, J.A. and Ackermann, B.L. Bioanalysis 8, no. 15 (2016): 1579-1595.
- 1 Lilly Research Laboratories, Eli Lilly & Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
"The OXM peptides 1–37, 3–37 and 4–37 as well as their corresponding stable isotope-labeled internal standards (each containing one [ 13 C 9 , 15 N]-labeled phenylalanine and two [ 13 C 6 , 15 N]-labeled leucine residues) were synthesized by CPC Scientific, Inc."
June 17th, 2016Citations, Isotope-Labeled PeptidesCuperus, T., van Dijk, A., Matthijs, M.G., Veldhuizen, E.J. and Haagsman, H.P. Scientific Reports 6, no. 1 (2016): 26622.
"D-CATH-2 (amino acid sequence: RFGRFLRKIRRFRPKVTITIQGSARF-NH2) and N-terminally FITC and TAMRA labeled peptides were generated by solid-phase synthesis using Fmoc-chemistry and purified to >95% purity by RP-HPLC by CPC Scientific Inc. (Sunnyvale, USA…"
May 27th, 2016Citations, Dye-LabeledChikh, G., Luu, R., Patel, S., Davis, H.L. and Weeratna, R.D. Vaccines 4, no. 2 (2016): 14.
- Pfizer Vaccine Immunotherapeutics, Ottawa Laboratories, Ottawa, ON K2K 3A2, Canada
KLK peptide (KLKL5KLK) and KPK peptide (KPKP5KPK) were synthesized by CPC Scientific, San Jose, CA, USA.
May 4th, 2016Citations